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KMID : 0043320160390030321
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Archives of Pharmacal Research
2016 Volume.39 No. 3 p.321 ~ p.327
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Identification of new pyrrole alkaloids from the fruits of Lycium chinense
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Youn Ui-Joung
Lee Joo-Yun
Kil Yun-Seo
Han Ah-Reum
Chae Chong-Hak
Ryu Shi-Yong
Seo Eun-Kyoung
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Abstract
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Three new minor pyrrole alkaloids, 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid (1), (2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-1-methoxy-1-oxobutanoic acid (2), and methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-4-methylpentanoate (3) were isolated from the fruits of Lycium chinense Miller (Solanaceae), along with the known compound, methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(phenyl)propanoate (4). The structures of 1-4 were elucidated by analysis of their 1D- and 2D-NMR and HRMS data. The absolute configurations of 2-4, possessing a stereogenic center in each structure, were determined by comparison of their experimental electronic circular dichroism (ECD) with those of calculated ECD values.
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KEYWORD
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Lycium chinense, Solanaceae, Pyrrole alkaloid, ECD, Absolute configuration
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